I was really pissed when I realized that iSync had disappeared after upgrading to OS X Lion. Suddenly, I had no mean to synchronize my cellular phone with my computer. I find this type of attitude very rude from Apple. Well, by chance I did not really upgrade. In fact, I installed OS X Lion on a new drive that I installed in my Macbook Pro. And I was keeping my old drive with OS X Snow Leopard as backup in case something goes wrong with the new drive or with Lion. The solution was to simply copy iSync from the Applications folder on my old drive to the same folder on my new drive. So now I have Lion with iSync.